Coadministration of encorafenib with delicate CYP3A4 substrates could bring about greater toxicity or diminished efficacy of those brokers.hydrocortisone will minimize the level or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.Cessation of benzodiazepines or other CNS depressants is desired most